A simple, precise, accurate and stability indicating UV-method have been developed and validated for estimation of Olmesartan. Many experiments were conducted by taking combination of drugs & also by single drug but no suitable validation with stability study was reported. Olmesartan has the absorbance maxima at 257nm.Method A involves method development and validation, showed sharp peak at 257nm.Method B involves forced degradation study. All the methods utilize methanol as solvent. Linearity for the detector response was observed in the concentration range of 5-35µg/ml. Validation experiments were performed to demonstrate System suitability, Specificity, Precision, Linearity, Accuracy Precision, robustness, ruggedness, LOD, &LOQ. Furthermore stability studies of Olmesartan were carried out under acidic, alkali, neutral, oxidation &photolytic degradation as per stability indicating assay methods. The results of analysis have been validated and recovery studies were carried out by adding specific drug amount (80%, 100%, 120%) and shows recovery studies in the range (99.45 -100.38) %. The proposed method can be successfully applied for method development, validation and stability study of Olmesartan.
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